SLC20A2 — Solute carrier family 20 member 2
SLC20A2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC20A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Apical junction complex Migration & adhesion | ARHGAP32, HEPH, KDM6A, KIAA1671, MYH14, NIPBL, PLEKHA7, POF1B +3 more | View in SCUBA |
About the gene
| Synonyms | Glvr-2, GLVR2, MLVAR, PiT-2, Ram-1 |
|---|---|
| Chromosome | 8: 42416475-42541926 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Host cell receptor for virus entry, Receptor |
| Biological process | Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport |
Function
Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.