FBXO32 — F-box protein 32
FBXO32 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FBXO32's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Hypoxia Metabolic Stress Stress | ADGRE5, ANKRD37, ARL4A, IRS2, KLF2, LRRFIP1, SKIL, TENT5A | View in SCUBA |
| Smooth muscle cells | Atrophy Proteolysis Program Stress | ARL6IP5, CTDSP2, FOXP1, GLUL, SERINC3, SQSTM1, UBE2B | View in SCUBA |
About the gene
| Synonyms | ATROGIN1, Fbx32, MAFbx |
|---|---|
| Chromosome | 8: 123497889-123541206 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.