SMC5 — Structural maintenance of chromosomes 5
SMC5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMC5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA stability regulation Immune regulation | APLP2, ARID5B, CARHSP1, GK, GLCCI1, GRAMD4, HIVEP1, METTL8 +12 more | View in SCUBA |
| Gamma-delta T cells | Spliceosome Regulation RNA processing & translation | AFF1, ATOSA, CEP95, CSNK1A1, FAM13B, KANSL3, KIF5B, MYSM1 +15 more | |
| Macrophages | Ubiquitin-Proteasome Regulation Housekeeping | ABCA1, AVL9, EHMT1, GIGYF2, HUWE1, LCORL, PAXBP1, PPP2R2D +4 more | View in SCUBA |
About the gene
| Synonyms | KIAA0594, SMC5L1 |
|---|---|
| Chromosome | 9: 70258978-70354873 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, Mitosis |
Function
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.