Spliceosome Regulation
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 24 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 24 genes have a known function matching the annotation |
Why this annotation
Top hub genes SREK1 (splicing regulatory), PNN (pre-mRNA splicing scaffold), PRP4K (spliceosomal kinase), PRPF40A (spliceosome component), TCERG1 (transcription-splicing coupling factor), and SMC5 (structural maintenance of chromosomes for DNA repair) define a co-transcriptional RNA processing and chromatin integrity program. MYSM1 (histone H2A deubiquitinase), ZBTB11, ZNF207, ZNF335, ZBTB38 are chromatin/transcriptional regulators. KIF5B and SEPTIN2 suggest cytoskeletal organization. The dominant theme is spliceosome function and chromatin regulation, coherent and uniform across subsets.
Genes
AFF1, ATOSA, CEP95, CSNK1A1, FAM13B, KANSL3, KIF5B, MYSM1, PNN, PRP4K, PRPF40A, PSPC1, SEPTIN2, SLTM, SMC5, SREK1, STX16, TAB2, TCERG1, ZBTB11, ZBTB38, ZNF107, ZNF207, ZNF335
Most correlated modules
- Centrosome Organization · correlation 0.92
- Chromatin Remodeling Signaling · correlation 0.89
- Wnt-STAT3 Signaling · correlation 0.86
- Mitochondrial RNA Processing · correlation 0.86
- T Cell Migration · correlation 0.85
- Transcriptional Coactivation · correlation 0.83
- Post-transcriptional RNA Regulation · correlation 0.83
- DNA Damage Response · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.