mRNA stability regulation
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 21 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes are predominantly transcription/RNA-regulatory factors: ZNF281, MSI2 (RNA-binding), HIVEP1 (NF-kB-related zinc finger), ARID5B (IL-6/Th17 regulator), ZC3H12D (Regnase family RNase, inflammation control), CARHSP1, METTL8. ARID5B and ZC3H12 family regulate inflammatory mRNA stability in T cells. TBC1D4, GK metabolic. Module reflects a post-transcriptional/transcriptional regulation of inflammatory activation program. Inflammation-associated and treatment-reversed.
Genes
APLP2, ARID5B, CARHSP1, GK, GLCCI1, GRAMD4, HIVEP1, METTL8, MPG, MSI2, MYL6B, NCOA1, NPDC1, PHACTR2, RYBP, SMC5, TBC1D4, TSPO, UBE2B, ZC3H12D, ZNF281
Most correlated modules
- MAPK feedback signaling · correlation 0.91
- Cell cycle regulators · correlation 0.88
- MAF regulatory program · correlation 0.86
- Activated Treg · correlation 0.84
- Activated effector Tcell · correlation 0.83
- NF-kB feedback · correlation 0.81
- T-cell activation · correlation 0.81
- Regulatory T cell · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.