SMYD3 — SET and MYND domain containing 3
SMYD3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMYD3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Membrane trafficking Housekeeping | BCL2, CLSTN1, GLB1, GTF2I, HPSE, HSDL2, LENG8, MBIP +19 more | View in SCUBA |
| Lymphatic endothelial | Cilia Centrosome Program Cytoskeletal | ARB2A, BBS9, BCAS3, CDKAL1, CEP112, EPB41L4A, FCHSD2, FTO +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ANK3, ARHGAP15, ARL15, BCAS3, CAMKMT, CCDC91, DPYD, EDA +13 more |
About the gene
| Synonyms | KMT3E, ZMYND1, ZNFN3A1 |
|---|---|
| Chromosome | 1: 245749342-246507312 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Methyltransferase, Transferase |
Function
Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.