STAMBPL1 — STAM binding protein like 1
STAMBPL1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
STAMBPL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Lysosomal proteases Protein processing & ER | CD63, CD82, CNPY3, CTSA, CTSC, CTSD, CTSZ, FUT8 +2 more | View in SCUBA |
| CD4⁺ T cells | IL10/cytokine signaling Immune regulation | CASK, CCDC141, FOXN3, IL10RA, IL7, SLC12A6, TMEM154, TNFRSF13B +4 more | View in SCUBA |
| Gamma-delta T cells | TCR Signal Regulation TCR Signaling | ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CDC14A, CXCR6 +22 more |
About the gene
| Synonyms | ALMalpha, AMSH-FP, AMSH-LP, bA399O19.2, FLJ31524, KIAA1373 |
|---|---|
| Chromosome | 10: 88879734-88975153 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
| Biological process | Ubl conjugation pathway |
Function
Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys- 63'-linked deubiquitination of SESN2, thereby inhibiting SESN2- interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.