Lysosomal proteases
Gene co-expression module in CD19⁺ B cells
| Category | Protein processing & ER |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Dominated by lysosomal cathepsins (CTSZ, CTSC, CTSD, CTSA), GRN (progranulin), CD63, PSAP-like lysosomal/antigen-processing machinery. This is a clear lysosomal/endolysosomal protease program associated with antigen processing and presentation, characteristic of activated/antigen-presenting B cells.
Genes
CD63, CD82, CNPY3, CTSA, CTSC, CTSD, CTSZ, FUT8, GALNT1, GRN, STAMBPL1
Most correlated modules
- Activated B cell · correlation 0.89
- Tissue-resident memory B · correlation 0.86
- B cell activation · correlation 0.81
- Atypical memory B cell · correlation 0.78
- ER/vesicle trafficking · correlation 0.78
- TNF/NF-kB response · correlation 0.74
- Cytoskeleton/motility · correlation 0.71
- Membrane adhesion remodeling · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.