TCHP — Trichoplein keratin filament binding
TCHP belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TCHP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Antiviral ISG Response Inflammation | ACTR1A, ATRX, CD164, CYTH4, FGD3, GIT2, LASP1, PARP10 +6 more | |
| Mucosal-associated invariant T cell | Endosomal Actin Organization Cytoskeletal | ARHGEF2, ATF6B, CGGBP1, FUT11, IARS2, ICE2, INPP5B, SH3BP2 +7 more |
About the gene
| Synonyms | MGC10854, TpMs |
|---|---|
| Chromosome | 12: 109900264-109983841 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis, Cilium biogenesis/degradation |
Function
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Is a negative regulator of ciliogenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.