IARS2 — Isoleucyl-tRNA synthetase 2, mitochondrial
IARS2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IARS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Interferon Antiviral Response Inflammation | ANKRD44, DDX17, DDX60L, KIAA0319L, KRBOX5, LZIC, MIA2, PIK3CD +14 more | |
| Lymphatic endothelial | ECM Remodeling TGFb migration & adhesion | CCDC80, CCND1, CHRDL1, CRIP1, CTSH, ECSCR, HS3ST1, LAMB2 +8 more | View in SCUBA |
| Macrophages | Autophagy Vesicular Trafficking Vesicular traficking | ACTR2, AHCYL1, ALKBH5, BECN1, BICD2, CAP1, CAPRIN1, COLGALT1 +32 more | View in SCUBA |
| Mucosal-associated invariant T cell | Endosomal Actin Organization Cytoskeletal | ARHGEF2, ATF6B, CGGBP1, FUT11, ICE2, INPP5B, SH3BP2, SMC1A +7 more |
About the gene
| Synonyms | FLJ10326 |
|---|---|
| Chromosome | 1: 220094132-220148041 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Aminoacyl-tRNA synthetase, Ligase |
| Biological process | Protein biosynthesis |
Function
Aminoacyl-tRNA synthetase that catalyzes the specific attachment of isoleucine to its cognate tRNA (tRNA(Ile))
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.