Endosomal Actin Organization
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Cytoskeletal |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
SNX1 (sorting nexin, endosomal trafficking), TMOD3 (tropomodulin, actin filament capping), TRAF5 (TNF receptor-associated factor 5, NF-κB signaling), FUT11 (fucosyltransferase), ARHGEF2 (RhoGEF, cytoskeletal regulation), CGGBP1 (CGG-binding protein, chromatin), ZNF512 (zinc finger), IARS2 (mitochondrial isoleucyl-tRNA synthetase), INPP5B (phosphoinositide 5-phosphatase), ICE2 (RNA processing), ATF6B (ER stress/UPR), SMC1A (cohesin, chromosome organization), SH3BP2 (adaptor in immune signaling), ZNF146. The module is mixed: TMOD3+ARHGEF2 suggest cytoskeletal organization; TRAF5+SH3BP2 suggest immune signaling; SNX1+INPP5B suggest endosomal trafficking; ATF6B suggests ER stress. With TMOD3 and ARHGEF2 as high-ranking cytoskeletal genes alongside endosomal trafficking components, and TRAF5 representing immune signaling, this module may represent a cytoskeletal/vesicle trafficking program in T cells. Overall the cytoskeletal theme is modest.
Genes
ARHGEF2, ATF6B, CGGBP1, FUT11, IARS2, ICE2, INPP5B, SH3BP2, SMC1A, SNX1, TCHP, TMEM87B, TMOD3, TRAF5, ZNF146, ZNF512
Most correlated modules
- Nuclear regulatory housekeeping · correlation 0.85
- Chromatin Maintenance State · correlation 0.85
- Chromatin Complex Regulation · correlation 0.83
- SWI/SNF Chromatin Remodeling · correlation 0.83
- Chemokine Receptor Migration · correlation 0.82
- NF-κB Immune Survival · correlation 0.81
- T cell Activation Signaling · correlation 0.76
- Integrin Actin Adhesion · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.