Antiviral ISG Response
Gene co-expression module in Gamma-delta T cells
| Category | Inflammation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
SAMD9L is a well-characterized interferon-stimulated gene (ISG) with antiviral functions. XAF1 is an ISG that antagonizes XIAP and promotes apoptosis in infected cells. TAP1 is an ISG involved in MHC-I antigen presentation. TRIM38 is an E3 ubiquitin ligase with antiviral activity. PARP10 has antiviral mono-ADP-ribosylation activity. RGS3 modulates GPCR-mediated immune signaling. ATRX participates in innate sensing of viral DNA. This module represents an interferon-stimulated antiviral gene program in gd_T cells.
Genes
ACTR1A, ATRX, CD164, CYTH4, FGD3, GIT2, LASP1, PARP10, RGS3, RNF44, SAMD9L, TAP1, TCHP, TRIM38, XAF1
Most correlated modules
- Butyrophilin gd Activation · correlation 0.88
- ER Glycoprotein Quality Control · correlation 0.85
- TGF-beta Signaling · correlation 0.82
- Interferon Stimulated Genes · correlation 0.81
- T cell Survival · correlation 0.79
- TCR Activation Signaling · correlation 0.79
- Chromatin Epigenetic Regulation · correlation 0.76
- mTOR-Exocyst Signaling · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.