PARP10 — Poly(ADP-ribose) polymerase family member 10
PARP10 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PARP10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Antiviral ISG Response Inflammation | ACTR1A, ATRX, CD164, CYTH4, FGD3, GIT2, LASP1, RGS3 +6 more | |
| Macrophages | Antiviral ISG Response Antiviral | ADAR, APOL6, ARID5A, CLEC7A, DDX60, DTX3L, EIF2AK2, ERICH1 +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | ABCF2, ACAA2, ANXA2R, BST2, CHST12, IRF9, LY6E, LYSMD2 +6 more |
About the gene
| Synonyms | ARTD10, FLJ14464 |
|---|---|
| Chromosome | 8: 143977153-144012772 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Nucleotidyltransferase, Transferase |
| Biological process | DNA damage, DNA repair |
Function
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.