TFF1 — Trefoil factor 1
TFF1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TFF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Inflammatory goblet response Immune function | ANXA1, B4GALT1, CAPN8, CEACAM6, DST, KRT20, LYPD8, MUC13 +8 more | View in SCUBA |
About the gene
| Synonyms | BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 |
|---|---|
| Chromosome | 21: 42362282-42366535 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Growth factor |
Function
Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.