LYPD8 — LY6/PLAUR domain containing 8
LYPD8 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LYPD8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Surface colonocyte transport Absorption | CA4, CD46, CITED1, CLCN1, DOCK4, GSN, HSPB1, ITM2C +4 more | View in SCUBA |
| Goblet cells | Inflammatory goblet response Immune function | ANXA1, B4GALT1, CAPN8, CEACAM6, DST, KRT20, MUC13, MXD1 +8 more | View in SCUBA |
About the gene
| Chromosome | 1: 248739415-248755759 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
Function
Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.