TMEM63A — Transmembrane protein 63A
TMEM63A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM63A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Death Receptor Apoptosis Stress | CXCR3, FHL3, GABARAPL2, LDLRAP1, LY6E, PDGFB, PLSCR3, SGSM3 +4 more | |
| Mucosal-associated invariant T cell | Chromatin Maintenance State DNA/chromatin regulation | ATRX, DYRK2, GART, KIF2A, PILRB, RBL2, S1PR5, SH2D1A +3 more |
About the gene
| Synonyms | KIAA0792 |
|---|---|
| Chromosome | 1: 225845536-225882380 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Ion channel |
| Biological process | Ion transport, Transport |
Function
Mechanosensitive cation channel with low conductance and high activation threshold. In contrast to TMEM63B, does not show phospholipid scramblase activity. Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (By similarity). Important for the baby's first breath and respiration throughout life. Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace. Also acts as an osmosensitive cation channel preferentially activated by hypotonic stress (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.