TRERF1 — Transcriptional regulating factor 1
TRERF1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRERF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T Cell Identity Program T cell maturation | ADA2, ADAM10, ARHGAP12, ATM, LPP, NLRC5, PIKFYVE, PJA2 +5 more | |
| Mucosal-associated invariant T cell | Cellular Maintenance Housekeeping | DCTN4, FAM13B, GBF1, GOLGA4, GPRIN3, HUWE1, ITSN2, PAFAH1B1 +4 more |
About the gene
| Synonyms | BCAR2, dJ139D8.5, HSA277276, RAPA, TReP-132 |
|---|---|
| Chromosome | 6: 42224931-42452051 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.