Cellular Maintenance
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
This module contains genes involved in diverse regulatory and structural processes with uniform expression across subsets, suggesting a housekeeping/constitutive cellular maintenance program. Key hub genes include PAFAH1B1 (LIS1, microtubule/dynein regulator), GPRIN3 (G-protein signaling), FAM13B (RhoGAP domain), PPP6R3 (phosphatase regulatory subunit), PRDM2 (transcriptional repressor), ITSN2 (endocytic scaffold), HUWE1 (E3 ubiquitin ligase), GOLGA4/GBF1 (Golgi organization), DCTN4 (dynactin subunit), SENP5 (SUMO protease), SERINC1 (serine incorporator), and TRERF1 (transcription factor). These span Golgi trafficking, cytoskeletal regulation, ubiquitin/SUMO modification, and general transcription — a mixed but coherent housekeeping/cell maintenance signature. No immune-specific activation program is evident. The uniform expression and low pct positive are consistent with constitutive low-level maintenance programs active in a subset of cells.
Genes
DCTN4, FAM13B, GBF1, GOLGA4, GPRIN3, HUWE1, ITSN2, PAFAH1B1, PPP6R3, PRDM2, SENP5, SERINC1, TRERF1
Most correlated modules
- Nuclear-Cytoplasmic Transport · correlation 0.86
- Circadian Transcriptional Regulation · correlation 0.82
- Cytoskeletal Organization · correlation 0.81
- T cell Homeostasis · correlation 0.79
- TCR Activation Signaling · correlation 0.78
- Nuclear-Cytoskeletal Organization · correlation 0.77
- Post-translational Regulation · correlation 0.77
- Transcription Factor Activity · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.