DCTN4 — Dynactin subunit 4
DCTN4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DCTN4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Ubiquitin-p53 Regulation Protein processing & ER | ATXN7, CCNL1, FNBP1, HERPUD2, MOB4, RBBP6, RNF139, TP53BP2 +4 more | |
| Macrophages | MITF Lysosomal Program Lysosomal & pahgocytosis | ABHD3, ANKRD44, ARSB, C2CD5, CERS6, CHST11, CNST, FBXL20 +25 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cellular Maintenance Housekeeping | FAM13B, GBF1, GOLGA4, GPRIN3, HUWE1, ITSN2, PAFAH1B1, PPP6R3 +4 more |
About the gene
| Synonyms | Dyn4, p62 |
|---|---|
| Chromosome | 5: 150708440-150759095 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.