TRPS1 — Transcriptional repressor GATA binding 1
TRPS1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRPS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | MAF regulatory program Immune regulation | AKAP13, ARID4B, DTHD1, FYN, IKZF3, ISCU, LIMA1, LIMS1 +12 more | View in SCUBA |
| CD8⁺ T cells | CD8 Effector Maturation T cell maturation | AKAP13, ATXN1, CD81, DDX17, DDX3X, ETS1, IKZF3, JUND +8 more | View in SCUBA |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more | View in SCUBA |
About the gene
| Synonyms | GC79, LGCR |
|---|---|
| Chromosome | 8: 115408496-115809673 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.