JUND — JunD proto-oncogene, AP-1 transcription factor subunit

JUND belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

JUND's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	AP-1 Immediate Early BCR/AP1/NFKb pathway	BTG2, CD69, CD83, DUSP1, EIF1, FOS, FOSB, JUN +7 more	View in SCUBA
CD4⁺ T cells	Glucocorticoid Immunoregulation Immune regulation	AHNAK, BTG1, CRIP1, GGNBP2, IDS, INSIG1, IRS2, KLF6 +11 more	View in SCUBA
CD8⁺ T cells	CD8 Effector Maturation T cell maturation	AKAP13, ATXN1, CD81, DDX17, DDX3X, ETS1, IKZF3, MXD4 +8 more	View in SCUBA
Endothelial	Shear Stress Response Stress	DNAJB1, DUSP1, EGR1, FOS, FOSB, HES1, HSP90AA1, HSPA1A +11 more	View in SCUBA
Enterocytes	Mature colonocyte absorptive Absorption	ADI1, BRI3, BTG1, CAMK2N1, CTSZ, FXYD3, GUCA2A, GUCA2B +9 more	View in SCUBA
Gamma-delta T cells	GPCR-AKT-MAPK Signaling TCR Signaling	ADNP, AKT1, ALYREF, B3GALT6, BRD4, BRI3, BTBD6, CENPB +29 more
Goblet cells	Immediate Early Gene chromatin regulation & transcription	BTG2, DUSP1, EGR1, FOS, FOSB, IER2, JUN, JUNB	View in SCUBA
Innate lymphoid cells	AP-1 Transcriptional Activation DNA regulation & transcription	AHNAK, ALYREF, CD81, CDV3, CITED4, ESYT2, ETS1, GNAI2 +28 more	View in SCUBA
Lymphatic endothelial	AP-1 Immediate Early Inflammation	DUSP1, EGR1, FOS, FOSB, HES1, HSPA8, IER2, JUN +7 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Mucosal-associated invariant T cell	Heat Shock Response Stress	ANKRD37, DNAJB1, HSP90AA1, HSP90AB1, HSPA8, RGS2, UBB, UBC
Pericytes	Immediate Early Gene Stress	DNAJB1, EGR1, FOS, FOSB, HSPA1A, HSPA1B, IER2, JUN +3 more	View in SCUBA
Smooth muscle cells	Notch-TGFbeta Signaling Development	AHI1, CD81, CD9, CPED1, EDIL3, FHL1, GSN, MAF +3 more	View in SCUBA

About the gene

Synonyms	AP-1
Chromosome	19: 18279694-18281622
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Function

Transcription factor binding AP-1 sites. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.