TSG101 — Tumor susceptibility 101
TSG101 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TSG101's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB regulation TCR/AP1/NFKb pathway | ARIH2, CD58, CYLD, DAD1, DERL1, EED, ELOVL5, NFAT5 +9 more | View in SCUBA |
| Macrophages | RAS-MAPK Signaling Housekeeping | ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1 +26 more | View in SCUBA |
About the gene
| Synonyms | TSG10, VPS23 |
|---|---|
| Chromosome | 11: 18468336-18526951 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Growth regulation, Host-virus interaction, Protein transport, Transport |
Function
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan. It may also play a role in the extracellular release of microvesicles that differ from the exosomes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.