ARPC2 — Actin related protein 2/3 complex subunit 2

ARPC2 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ARPC2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Actin Cytoskeleton Cytoskeletal	ACTB, ACTG1, ACTR3, ARPC1B, ARPC4, ARPC5, BRK1, CAP1 +14 more	View in SCUBA
CD4⁺ T cells	Actin cytoskeleton Cytoskeletal	ACTB, ACTG1, ARPC3, CLIC1, COPE, ELOB, GAPDH, PFN1 +3 more	View in SCUBA
CD8⁺ T cells	Actin Cytoskeleton Dynamics Cytoskeletal	ACTG1, ACTR3, ANXA11, CAP1, CDK2AP2, RAC2, RNF181	View in SCUBA
Endothelial	Rho-Actin Remodeling Cytoskeletal	ANAPC11, ARPC5, ATP6V0B, GNAI2, HNRNPH3, HRAS, KIF5B, PDAP1 +9 more	View in SCUBA
Fibroblasts	ER Protein Processing Vesicular traficking	ENO1, GTF3C6, KDELR2, LMAN1, OSTC, P4HB, PRDX4, PSMC4 +5 more	View in SCUBA
Gamma-delta T cells	Cytotoxic Effector Actin cytotoxicity	ARPC5, ATOX1, BRK1, CFL1, CLIC1, CORO1A, DBI, MYL12B +14 more
Glial cells	ER Translocon Activity Protein processing & ER	CALR, EDF1, MRPL52, MYL6, NDUFA1, OST4, PFN1, PPIB +3 more	View in SCUBA
Goblet cells	Ubiquitin Protein Homeostasis Housekeeping	BZW1, CMTM6, CSNK1A1, DAP, EMP2, GNAI3, KIF5B, MORF4L1 +6 more	View in SCUBA
Innate lymphoid cells	Actin Cytoskeleton Remodeling Cytoskeleton & motility	APRT, ARPC3, ATP5F1E, ATP6V0E1, C11orf58, CFL1, CHCHD2, COX6C +17 more	View in SCUBA
Lymphatic endothelial	Proteasome Assembly Protein processing & ER	CSTB, DEGS1, GSTO1, MRPL14, PDCD5, POMP, PRELID1, PSMD7 +5 more	View in SCUBA
Neutrophils	Pentose Phosphate Pathway Housekeeping	ANXA3, CAP1, CDA, GYG1, HMGB2, LBR, PGD, SNX3 +1 more
Smooth muscle cells	Basal Metabolic Housekeeping Housekeeping	C11orf58, C1orf43, C4orf3, CNBP, COX17, GUK1, HNRNPDL, HNRNPH2 +6 more	View in SCUBA

About the gene

Synonyms	ARC34, p34-Arc
Chromosome	2: 218217141-218254356
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Actin-binding

Function

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.