RAS-MAPK Signaling
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 35 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 35 genes have a known function matching the annotation |
Why this annotation
Hub genes include UBE2D2/UBE2B (ubiquitin-conjugating E2 enzymes), KRAS (RAS proto-oncogene, MAPK signaling), SHOC2 (RAS scaffold/MAPK activator), RAP1B (small GTPase), RAB2A (vesicle trafficking GTPase), PSMD12 (proteasome 26S subunit), RHEB (mTOR activator GTPase), JAK1 (Janus kinase), CDC37/STIP1 (HSP90 co-chaperones). The module combines ubiquitin-proteasome (UBE2D2, UBE2B, PSMD12, ZFAND6), RAS/MAPK signaling (KRAS, SHOC2, RAP1B), and chaperone activity (CDC37, STIP1). The RAS-MAPK signaling theme is notable with KRAS and SHOC2 as co-hubs. This is a mixed housekeeping module with RAS signaling and ubiquitin-proteasome as co-themes in mono_mac.
Genes
ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1, JAK1, KRAS, LIMS1, MED4, MIER1, MORC3, PFDN1, PHC2, PITPNA, PPP4R2, PSMD12, PTPN12, RAB2A, RAP1B, RBM3, RHEB, RIOK3, RNF10, SEC13, SHOC2, STIP1, TSG101, UBE2B, UBE2D2, UBE2J2, YWHAZ, ZFAND6
Most correlated modules
- RNA Splicing Regulation · correlation 0.97
- Endolysosomal Trafficking · correlation 0.95
- Ubiquitin-Proteasome System · correlation 0.95
- RNA Processing Regulation · correlation 0.95
- Microtubule Organization · correlation 0.94
- Golgi-Endosome Trafficking · correlation 0.93
- Protein Biogenesis · correlation 0.92
- Transcriptional Elongation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.