ARHGDIA — Rho GDP dissociation inhibitor alpha
ARHGDIA belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGDIA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Rho GTPase Cytoskeletal Cytoskeletal | BUD31, CYB5B, MORF4L1, PIN1, POLR2G, PPP4C, PSMB7, RAC1 +5 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing RNA processing & translation | DDX27, DDX59, EIF2AK1, EWSR1, FBXL5, GNL1, GTF2F1, HNRNPM +14 more | |
| Innate lymphoid cells | mRNA Translation RNA processing & translation | ABHD14B, CD2BP2, EEF2, EIF3L, GYPC, H2AJ, HNRNPA0, HNRNPDL +6 more | View in SCUBA |
| Macrophages | Actin Cytoskeleton Organization Cytoskeletal | ACTR3, ARF1, ARPC4, CDC42, DERL1, EIF4G2, GARS1, HNRNPK +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Housekeeping Translation Housekeeping | ARHGEF1, CCNI, DAZAP2, EEF2, HLA-A, HLA-B, HNRNPA1, PABPC1 +4 more |
About the gene
| Synonyms | GDIA1, RHOGDI |
|---|---|
| Chromosome | 17: 81867721-81871378 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.