ETFA — Electron transfer flavoprotein subunit alpha
ETFA belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ETFA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Oxidative phosphorylation Mitochondrial & OxPhos | ACADVL, CHMP1A, COX14, EIF2AK1, EML2, GPR108, NDUFA8, PARP1 +12 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Lysosomal Housekeeping Mitochondrial & OxPhos | BTF3L4, C14orf119, EMC6, IER3IP1, JTB, LAMP1, MRPL14, MRPS16 +7 more | View in SCUBA |
| Macrophages | RAS-MAPK Signaling Housekeeping | ARF4, ATG12, CAMTA1, CDC37, CHMP4B, GLA, HMGA1, JAK1 +26 more | View in SCUBA |
About the gene
| Synonyms | EMA, GA2, MADD |
|---|---|
| Chromosome | 15: 76188555-76311730 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | Electron transport, Transport |
Function
Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.