UBE2E2 — Ubiquitin conjugating enzyme E2 E2
UBE2E2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE2E2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Hippo-Adhesion Signaling migration & adhesion | ANKRD17, DOCK4, FER, GPHN, PRKCE, PTPRM, STAG1, STK3 +1 more | View in SCUBA |
| Macrophages | Transcriptional Kinase Regulation Housekeeping | BNC2, CABLES1, CACNB4, CDK8, ENOX2, FAF1, FOXO1, INPP4B +17 more | View in SCUBA |
About the gene
| Synonyms | FLJ25157, UbcH8 |
|---|---|
| Chromosome | 3: 23203020-23591794 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.