PTPRM — Protein tyrosine phosphatase receptor type M
PTPRM belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTPRM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Quiescence Identity Endothelial cell development | ABCC4, ARHGAP5, C1orf115, ENPP4, FAM107A, GIT2, IFNAR2, LRRFIP1 +8 more | View in SCUBA |
| Fibroblasts | Wnt-BMP Fibroblast Developmental | ABCC4, BMP7, EMID1, ETS1, GJA1, GNG2, LEF1, MFGE8 +5 more | View in SCUBA |
| Lymphatic endothelial | Hippo-Adhesion Signaling migration & adhesion | ANKRD17, DOCK4, FER, GPHN, PRKCE, STAG1, STK3, UBE2E2 +1 more | View in SCUBA |
About the gene
| Synonyms | hR-PTPu, PTPRL1, RPTPU |
|---|---|
| Chromosome | 18: 7566782-8406861 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Protein phosphatase, Receptor |
| Biological process | Cell adhesion |
Function
Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation. Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.