Hippo-Adhesion Signaling
Gene co-expression module in Lymphatic endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
STK3 (MST2, Hippo pathway kinase), DOCK4 (Rac1 GEF promoting migration/morphogenesis), PTPRM (receptor phosphatase regulating cell-cell adhesion), and FER (non-receptor tyrosine kinase linking adhesion to actin) define a Hippo/adhesion signaling module. PRKCE (PKC epsilon) and GPHN (cytoskeletal scaffold) support signaling/cytoskeletal roles. STAG1 (cohesin) may reflect chromatin-level co-regulation. The Hippo pathway (STK3/MST2) is a key regulator of LEC identity and lymphangiogenesis. Neighbor context: shares kinase/GEF themes with M44 and M38.
Genes
ANKRD17, DOCK4, FER, GPHN, PRKCE, PTPRM, STAG1, STK3, UBE2E2, ZFAND3
Most correlated modules
- Chromatin Remodeling · correlation 0.97
- Actin-based Migration · correlation 0.96
- Rho/Ras GTPase Regulation · correlation 0.96
- Focal Adhesion Migration · correlation 0.95
- Cilia Centrosome Program · correlation 0.95
- MAPK-ERK Signaling · correlation 0.94
- Inflammatory cAMP Response · correlation 0.94
- Polarized Vesicle Trafficking · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.