STAG1 — Stromal antigen 1
STAG1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
STAG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Hippo-Adhesion Signaling migration & adhesion | ANKRD17, DOCK4, FER, GPHN, PRKCE, PTPRM, STK3, UBE2E2 +1 more | View in SCUBA |
| Macrophages | Golgi Vesicle Trafficking Vesicular traficking | ARMH3, ATG7, CCDC91, CDK17, CLASP1, COG5, COMMD10, COP1 +24 more | View in SCUBA |
| Neutrophils | ELMO-DOCK Chemotaxis Chemotaxis | BCAS3, CDK19, DOCK2, ELMO1, KMT2C, NCOA2, VPS13B |
About the gene
| Synonyms | SA-1, SA1, SCC3A |
|---|---|
| Chromosome | 3: 136336236-136752403 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Chromosome partition, Mitosis |
Function
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.