UCHL5 — Ubiquitin C-terminal hydrolase L5
UCHL5 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UCHL5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Damage Repair DNA/chromatin regulation | AGGF1, ANP32A, DCK, DDX46, HADHA, HDDC2, HENMT1, IFNAR1 +8 more | |
| Macrophages | Replication Chromatin Assembly Cell cycle | ANP32B, CBX3, CDK4, COPS3, DEK, DNMT1, EMC8, EXOSC8 +22 more | View in SCUBA |
About the gene
| Synonyms | CGI-70, INO80R, UCH37 |
|---|---|
| Chromosome | 1: 193012250-193060080 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
| Biological process | DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation, Ubl conjugation pathway |
Function
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.