DNMT1 — DNA methyltransferase 1

DNMT1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DNMT1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Cell Cycle G1/S Cell cycle	CARHSP1, CBX5, CENPM, GMNN, HMGB2, HMGN2, MND1, MYBL2 +8 more	View in SCUBA
CD8⁺ T cells	Epigenetic Chromatin Maintenance DNA/chromatin regulation	BAZ1B, DDX46, HNRNPAB, NASP, NOP56, SET, SMC1A, SMC3 +2 more	View in SCUBA
Endothelial	DNA Replication Cell cycle	CENPX, ICMT, IDH2, MCM3, MCM4, MCM5, MCM6, NR2C2AP +11 more	View in SCUBA
Gamma-delta T cells	Mitotic Spindle Cell cycle	CAPRIN1, CDK5RAP2, CKAP5, CNTRL, DEK, FAM111A, GMPS, HADH +11 more
Goblet cells	MCM Replication Licensing Cell cycle	CDT1, DUT, FAM111B, GINS2, HELLS, MCM3, MCM4, MCM5 +4 more	View in SCUBA
Hematopoietic progenitor cells	S-phase Progression Cell cycle	ATAD2, ATAD5, BRCA2, FANCI, LMNB1, RRM1, SMC2, TMPO +1 more
Innate lymphoid cells	NK Cytotoxic Regulation Cytotoxicity	ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27 +29 more	View in SCUBA
Macrophages	Replication Chromatin Assembly Cell cycle	ANP32B, CBX3, CDK4, COPS3, DEK, EMC8, EXOSC8, FDPS +22 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Activation Signaling TCR Signaling	AGAP2, ARHGAP45, CDK5RAP3, IL10RA, ITGAL, JADE2, NBR1, PLCB2 +6 more

About the gene

Synonyms	CXXC9, DNMT, MCMT
Chromosome	19: 10133342-10231286
Predicted location	Intracellular
Essential gene	Yes
Protein class	Disease related genes, Enzymes, Essential proteins, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors
Molecular function	Activator, Chromatin regulator, DNA-binding, Methyltransferase, Repressor, Transferase
Biological process	Transcription, Transcription regulation

Function

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS- mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.