Replication Chromatin Assembly
Gene co-expression module in Macrophages
| Category | Cell cycle |
|---|---|
| Genes | 31 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 31 genes have a known function matching the annotation |
Why this annotation
SSRP1 and SUPT16H encode the FACT complex (facilitates chromatin transcription), essential for replication-coupled chromatin reassembly. SMC1A and SMC3 are cohesin subunits required for sister chromatid cohesion. DEK and ANP32B are chromatin-associated proteins enriched in proliferating cells. DNMT1 performs replication-coupled DNA methylation maintenance. RBBP7 and CBX3 are chromatin remodeling factors. NOP56 supports ribosome biogenesis. This module reflects replication-coupled chromatin organization in S-phase, all enriched in prolif_mac.
Genes
ANP32B, CBX3, CDK4, COPS3, DEK, DNMT1, EMC8, EXOSC8, FDPS, HNRNPAB, ILF2, IMPDH2, MRPS11, NOLC1, NOP56, NUDT5, PA2G4, PGP, POLE3, PPM1G, PSMG3, RBBP7, SF3A3, SHMT2, SMC1A, SMC3, SNRPA1, SSRP1, SUPT16H, TPGS2, UCHL5
Most correlated modules
- Mitotic Spindle Assembly · correlation 0.96
- RNA Processing & Repair · correlation 0.93
- Spliceosomal snRNP · correlation 0.93
- G1/S Transition · correlation 0.92
- ER Protein Glycosylation · correlation 0.90
- DNA Replication Metabolism · correlation 0.89
- Ribosome Biogenesis · correlation 0.89
- Centrosome & DNA Repair · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.