UGT2B17 — UDP glucuronosyltransferase family 2 member B17
UGT2B17 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UGT2B17's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Colonocyte Differentiation Program Epithelial development | ASCL2, CAMK1D, CDK6, EDIL3, ENTPD5, FOXN3, HMGCS2, IRF2BP2 +8 more | View in SCUBA |
About the gene
| Chromosome | 4: 68537173-68576413 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
| Biological process | Lipid metabolism, Steroid metabolism |
Function
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.