IRF2BP2 — Interferon regulatory factor 2 binding protein 2

IRF2BP2 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IRF2BP2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	TNF/NF-kB response BCR/AP1/NFKb pathway	ADGRE5, ATF3, BHLHE40, CHD1, CMTM6, CYLD, DUSP5, FMNL1 +7 more	View in SCUBA
CD4⁺ T cells	NFAT activation TCR/AP1/NFKb pathway	AHI1, ASAP1, BCAT1, BICDL1, CPM, CYP7B1, ETV6, FAM107B +13 more	View in SCUBA
Gamma-delta T cells	Late Activation Autophagy Immune regulation	BCL3, BRD1, CREM, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1 +19 more
Goblet cells	Colonocyte Differentiation Program Epithelial development	ASCL2, CAMK1D, CDK6, EDIL3, ENTPD5, FOXN3, HMGCS2, KLF5 +8 more	View in SCUBA
Innate lymphoid cells	Prostaglandin-AP1 Response Inflammation	ARIH1, ARL5B, CCNT1, CHD1, CXCL2, ETV3, FOSL2, JOSD1 +12 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	AMPK-FOXO Stress Response Stress	AHCTF1, C15orf39, FOXO3, FURIN, JARID2, MIDN, PRKAG2, TLE3	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Activation Inflammation	DUSP5, DUSP8, ELL2, GABARAPL1, MAFF, NAMPT, NFKB1, PER1 +8 more
Natural Killer cells	Circadian NF-κB Crosstalk Inflammation	DUSP8, ISCA1, MAP3K8, MED10, PER1, RELB, RHOH, SLC7A5	View in SCUBA
Neutrophils	RNA Splicing Housekeeping	ATF4, FUS, HNRNPA2B1, HNRNPA3, SFPQ, SRSF3, TRA2B

About the gene

Synonyms	IRF-2BP2
Chromosome	1: 234604269-234610178
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted intracellular proteins
Molecular function	Activator, Repressor
Biological process	Transcription, Transcription regulation

Function

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles. Plays a role in immature B-cell differentiation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.