VEZT — Vezatin, adherens junctions transmembrane protein
VEZT belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VEZT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Epigenetic regulation DNA/chromatin regulation | AFF4, ARID1B, CTSA, DGKH, FUBP1, JARID2, PDCD6, SYNCRIP +6 more | View in SCUBA |
| Macrophages | Endolysosomal Trafficking Vesicular traficking | ANKRD10, ATP1A1, ATP6V0A1, CHFR, CHML, FAR1, FBXL5, GSAP +21 more | View in SCUBA |
About the gene
| Synonyms | DKFZP761C241 |
|---|---|
| Chromosome | 12: 95217746-95302799 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
Function
Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.