ZFYVE28 — Zinc finger FYVE-type containing 28
ZFYVE28 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZFYVE28's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Rho-GTPase Migration migration & adhesion | ARHGAP18, ARHGEF7, FNBP1, HELZ, LPXN, MAP4K1, MIS18BP1, PREX1 +4 more | View in SCUBA |
| Endothelial | Glucocorticoid Response Inflammation | CCM2L, CFAP20, DUSP6, INAFM2, INHBB, MIER2, MYLIP, NUAK1 +6 more | View in SCUBA |
| Gamma-delta T cells | Osmotic Stress Response Stress | BAZ1A, BMPR2, HIPK3, HTT, LIX1L, MAPRE2, NFAT5, RALGAPB +6 more |
About the gene
| Synonyms | KIAA1643, lst-2 |
|---|---|
| Chromosome | 4: 2269582-2418651 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.