Glucocorticoid Response
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
The top hub gene TSC22D3 encodes GILZ (glucocorticoid-induced leucine zipper), a canonical glucocorticoid-responsive transcription factor with well-established anti-inflammatory roles in endothelial cells. DUSP6 is a MAPK/ERK phosphatase induced downstream of growth factor and glucocorticoid signaling. NUAK1 is an AMPK-related kinase involved in stress responses. PRDM1/Blimp-1 is a transcriptional repressor. MYLIP encodes MuRF/IDOL, an E3 ubiquitin ligase. INHBB (activin B) has anti-inflammatory roles. The module is significantly decreased during both UC and CD inflammation and recovers in remission, consistent with a homeostatic anti-inflammatory transcriptional program. The presence of TSC22D3 as a top hub strongly anchors this to glucocorticoid/anti-inflammatory signaling.
Genes
CCM2L, CFAP20, DUSP6, INAFM2, INHBB, MIER2, MYLIP, NUAK1, OAZ2, PELO, PRDM1, RILPL2, TSC22D3, ZFYVE28, ZNF503
Most correlated modules
- Glucocorticoid Response · correlation 0.88
- Venous Endothelial Identity · correlation 0.79
- Venous Endothelial Identity · correlation 0.79
- Endothelial Lipid Signaling · correlation 0.76
- Venous EC Identity · correlation 0.75
- IL-27 Receptor Signaling · correlation 0.74
- Arterial EC Identity · correlation 0.71
- Caveolae-mediated Transcytosis · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.