MAPRE2 — Microtubule associated protein RP/EB family member 2
MAPRE2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAPRE2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Osmotic Stress Response Stress | BAZ1A, BMPR2, HIPK3, HTT, LIX1L, NFAT5, RALGAPB, RTN4 +6 more | |
| Glial cells | ECM Homeostatic Regulation ECM remodeling | BPTF, KCTD12, OAF, SASH1, ST3GAL6, TIMP2, TTC3 | View in SCUBA |
| Macrophages | Chromatin Remodeling Housekeeping | ADIPOR2, ADNP, AP2A2, APPL2, ATF2, CDK19, CNOT1, CTDSPL2 +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | Apoptosis Regulation Immune regulation | ARF4, ARRDC3, CARD8, CFLAR, CREBZF, NABP1, PCF11, PPP1R10 +1 more |
About the gene
| Synonyms | EB1, EB2, RP1 |
|---|---|
| Chromosome | 18: 34976928-35143470 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability. Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation. Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.