MYLIP — Myosin regulatory light chain interacting protein

MYLIP belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MYLIP's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate early response Stress	ABHD5, CEBPB, CITED2, FAM53C, GADD45A, GADD45B, HEXIM1, HSPA2 +9 more	View in SCUBA
CD4⁺ T cells	Metabolic reprogramming Housekeeping	ATG16L2, ATP1A1, CCNYL1, CSKMT, EIF1AY, FAM241A, HMGCS1, ING1 +12 more	View in SCUBA
Endothelial	Glucocorticoid Response Inflammation	CCM2L, CFAP20, DUSP6, INAFM2, INHBB, MIER2, NUAK1, OAZ2 +6 more	View in SCUBA
Fibroblasts	Type I Interferon Inflammatory	ABHD5, HELZ2, ICAM4, IQCN, IRF7, IRF8, IRF9, LACTB +2 more	View in SCUBA
Gamma-delta T cells	AP-1 Immediate Early Response Stress	BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B +25 more
Glial cells	Glial Progenitor Identity Development	DLX2, ID2, ID4, IER5L, MARCKSL1, RGS2, SNAI1	View in SCUBA
Macrophages	Myeloid Signaling Regulation Innate immunity	ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A +38 more	View in SCUBA
Monocytes	AP-1 Stress Response Stress	BTG2, FOSB, PLK3, PMAIP1, PPP1R10, PPP1R15B, RGS2, VMP1 +1 more	View in SCUBA
Mucosal-associated invariant T cell	AP-1 Immediate Early Stress	AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, H2AX +17 more
Pericytes	Vascular Quiescence Developmental	HBEGF, ID2, KLF2, KLF4, MIDN, PLK2, RHOB, SAT1 +1 more	View in SCUBA

About the gene

Synonyms	IDOL, MIR
Chromosome	6: 16129086-16148248
Predicted location	Intracellular
Essential gene	No
Protein class	Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Transferase
Biological process	Ubl conjugation pathway

Function

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.