HIPK3 — Homeodomain interacting protein kinase 3
HIPK3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HIPK3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Quiescence Endothelial cell development | CCRL2, CDC42EP3, CGAS, CHSY1, CYTH1, HES5, ID1, ID3 +7 more | View in SCUBA |
| Gamma-delta T cells | Osmotic Stress Response Stress | BAZ1A, BMPR2, HTT, LIX1L, MAPRE2, NFAT5, RALGAPB, RTN4 +6 more | |
| Macrophages | Endosomal Vesicle Trafficking Vesicular traficking | ADAM17, AP3B1, ARFGEF1, ARID1B, ARK2N, ASAP1, ATF6, ATP11A +48 more | View in SCUBA |
| Neutrophils | Stress Kinase Signaling Stress | ANKRD44, APBB1IP, IGF1R, MAP3K5, MEF2A, NEK7, PARP8, RAP1GAP2 +2 more |
About the gene
| Synonyms | DYRK6, FIST3, PKY, YAK1 |
|---|---|
| Chromosome | 11: 33256672-33357023 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Apoptosis, Transcription, Transcription regulation |
Function
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2- mediated activation of the osteocalcin FGF-responsive element (OCFRE)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.