ZNF451 — Zinc finger protein 451
ZNF451 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZNF451's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Transcription/RNA processing RNA processing | ANKRD17, BDP1, CCDC97, CDK13, CHIC2, CLK4, CNOT6L, CRNKL1 +29 more | View in SCUBA |
| Gamma-delta T cells | Transcription-RNA Coupling DNA/chromatin regulation | AKNA, AP1G1, BTAF1, BZW1, CRNKL1, DDX6, DNTTIP2, DYNC1H1 +26 more | |
| Macrophages | Chromatin Regulatory Genes Housekeeping | ACAP2, ARID4A, ATRX, BPTF, BRD10, BRD4, EP300, ERBIN +31 more | View in SCUBA |
About the gene
| Synonyms | COASTER, dJ417I1.1, KIAA0576, KIAA1702, ZATT |
|---|---|
| Chromosome | 6: 57086844-57170305 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Transferase |
| Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Function
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1. Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11'. Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.