G1/S Replication
Gene co-expression module in CD19⁺ B cells
| Category | Cell cycle |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
MCM2/4/6 helicase complex, E2F1 transcription factor, POLD3, CHEK1, UHRF1, MSH2/6, CHAF1A define a G1/S replication-initiation and mismatch repair program. Core coherence and shared identity with neighbor M79 confirm a cell cycle S-phase module.
Genes
CDCA7, CHAF1A, CHEK1, E2F1, HELLS, MCM2, MCM4, MCM6, MSH2, MSH6, POLD3, UHRF1
Most correlated modules
- Replication Licensing · correlation 0.96
- DNA Replication · correlation 0.95
- Cell Cycle G1/S · correlation 0.94
- DNA Replication · correlation 0.94
- DNA Replication · correlation 0.91
- Mitotic Spindle · correlation 0.87
- Mitotic Spindle · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.