DNA Replication
Gene co-expression module in CD19⁺ B cells
| Category | Cell cycle |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes ATAD2, BRCA1, ORC6, ATAD5, ESCO2, RAD51AP1, LIG1, FANCI are all S-phase DNA replication and repair factors. MKI67 confirms proliferation. This is a core S-phase/DNA replication module. Neighbor modules M85 (replication) and M36 (mitosis) reinforce a cell cycle program.
Genes
ATAD2, ATAD5, BRCA1, CDCA4, E2F8, ESCO2, FANCI, FBXO5, LIG1, MKI67, ORC6, RAD51AP1, TCF19
Most correlated modules
- Replication Licensing · correlation 0.97
- Mitotic Spindle · correlation 0.96
- G1/S Replication · correlation 0.95
- Cell Cycle G1/S · correlation 0.92
- DNA Replication · correlation 0.91
- Mitotic Spindle · correlation 0.90
- DNA Replication · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.