DNA Replication
Gene co-expression module in CD19⁺ B cells
| Category | Cell cycle |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
SMC2 (condensin), UBE2T, TYMS, RRM2, ZWINT, LMNB1, VRK1, TFDP1 are classic S-phase/DNA replication and mitosis genes. Core proliferation module, neighbor of other cell cycle modules.
Genes
ACTL6A, LMNB1, RRM2, SAE1, SMC2, SSRP1, TFDP1, TYMS, UBE2T, VRK1, ZWINT
Most correlated modules
- Cell Cycle Proliferation · correlation 0.98
- Cell Cycle G1/S · correlation 0.97
- DNA Replication · correlation 0.97
- Replication Licensing · correlation 0.95
- Chromatin Remodeling · correlation 0.94
- RNA Processing · correlation 0.94
- Mitotic Spindle · correlation 0.94
- Mitochondrial Redox · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.