E2F1 — E2F transcription factor 1
E2F1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
E2F1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | G1/S Replication Cell cycle | CDCA7, CHAF1A, CHEK1, HELLS, MCM2, MCM4, MCM6, MSH2 +3 more | View in SCUBA |
| CD8⁺ T cells | MCM Helicase Loading Cell cycle | CDC45, CDCA7, DCTPP1, GINS2, HELLS, MCM2, MCM3, MCM4 +5 more | View in SCUBA |
| Hematopoietic progenitor cells | DNA Replication S-phase Cell cycle | CDT1, CENPH, CENPK, CHEK1, FEN1, GINS2, GMNN, PCLAF +4 more |
About the gene
| Synonyms | RBBP3, RBP3 |
|---|---|
| Chromosome | 20: 33675477-33686385 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Apoptosis, Cell cycle, Host-virus interaction, Transcription, Transcription regulation |
Function
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53- dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Directly activates transcription of PEG10. Positively regulates transcription of RRP1B.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.