HELLS — Helicase, lymphoid specific
HELLS belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HELLS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | G1/S Replication Cell cycle | CDCA7, CHAF1A, CHEK1, E2F1, MCM2, MCM4, MCM6, MSH2 +3 more | View in SCUBA |
| CD4⁺ T cells | CD200 immunoregulation Immune regulation | B3GNT2, CAV1, CD200, CD79A, CH25H, CHGB, DUOX1, ELF2 +23 more | View in SCUBA |
| CD8⁺ T cells | MCM Helicase Loading Cell cycle | CDC45, CDCA7, DCTPP1, E2F1, GINS2, MCM2, MCM3, MCM4 +5 more | View in SCUBA |
| Endothelial | S-phase DNA Replication Cell cycle | CHEK1, DNAJC9, FANCA, LIG1, MCM7, PCNA, RFC4, WDR76 | View in SCUBA |
| Gamma-delta T cells | DNA Replication Licensing Cell cycle | BRCA1, CHAF1A, MCM2, MCM3, MCM4, MCM5, MCM7, PAQR4 +2 more | |
| Goblet cells | MCM Replication Licensing Cell cycle | CDT1, DNMT1, DUT, FAM111B, GINS2, MCM3, MCM4, MCM5 +4 more | View in SCUBA |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
About the gene
| Synonyms | LSH, Nbla10143, PASG, SMARCA6 |
|---|---|
| Chromosome | 10: 94545329-94613905 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Developmental protein, Helicase, Hydrolase |
| Biological process | Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation |
Function
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.