MCM4 — Minichromosome maintenance complex component 4
MCM4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MCM4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | G1/S Replication Cell cycle | CDCA7, CHAF1A, CHEK1, E2F1, HELLS, MCM2, MCM6, MSH2 +3 more | View in SCUBA |
| CD8⁺ T cells | MCM Helicase Loading Cell cycle | CDC45, CDCA7, DCTPP1, E2F1, GINS2, HELLS, MCM2, MCM3 +5 more | View in SCUBA |
| Endothelial | DNA Replication Cell cycle | CENPX, DNMT1, ICMT, IDH2, MCM3, MCM5, MCM6, NR2C2AP +11 more | View in SCUBA |
| Gamma-delta T cells | DNA Replication Licensing Cell cycle | BRCA1, CHAF1A, HELLS, MCM2, MCM3, MCM5, MCM7, PAQR4 +2 more | |
| Goblet cells | MCM Replication Licensing Cell cycle | CDT1, DNMT1, DUT, FAM111B, GINS2, HELLS, MCM3, MCM5 +4 more | View in SCUBA |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
About the gene
| Synonyms | CDC21, CDC54, hCdc21, MGC33310, P1-Cdc21 |
|---|---|
| Chromosome | 8: 47960185-47978160 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | DNA-binding, Helicase, Hydrolase |
| Biological process | Cell cycle, DNA replication |
Function
Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.