CHAF1A — Chromatin assembly factor 1 subunit A
CHAF1A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHAF1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | G1/S Replication Cell cycle | CDCA7, CHEK1, E2F1, HELLS, MCM2, MCM4, MCM6, MSH2 +3 more | View in SCUBA |
| CD8⁺ T cells | DNA Replication Fork Cell cycle | CDC6, CDT1, CTNNAL1, DHFR, DUT, FEN1, LIG1, PCNA +5 more | View in SCUBA |
| Gamma-delta T cells | DNA Replication Licensing Cell cycle | BRCA1, HELLS, MCM2, MCM3, MCM4, MCM5, MCM7, PAQR4 +2 more |
About the gene
| Synonyms | CAF-1, CAF1, CAF1B, CAF1P150, MGC71229, P150 |
|---|---|
| Chromosome | 19: 4402640-4445018 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Chaperone, Chromatin regulator |
| Biological process | Cell cycle, DNA damage, DNA repair, DNA replication |
Function
Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.