Replication Licensing
Gene co-expression module in CD19⁺ B cells
| Category | Cell cycle |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 14 genes have a known function matching the annotation |
Why this annotation
CENPU/K, ASF1B, CDCA5, CDC6, CLSPN, CDT1, WDR76, USP1, FAM111B are replication licensing and chromatin assembly genes. Core S-phase/origin licensing module within the broader cell cycle neighborhood.
Genes
ASF1B, CDC6, CDCA5, CDT1, CENPK, CENPU, CLSPN, DNAJC9, FAM111B, ITGB3BP, TMEM106C, USP1, WDR76, YEATS4
Most correlated modules
- DNA Replication · correlation 0.97
- Cell Cycle G1/S · correlation 0.96
- DNA Replication · correlation 0.96
- G1/S Replication · correlation 0.96
- DNA Replication · correlation 0.95
- Mitotic Spindle · correlation 0.92
- Cell Cycle Proliferation · correlation 0.90
- Mitotic Spindle · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.